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Collagen and Extracellular Matrix Remodeling GHK-Cu activates fibroblasts, increasing the synthesis of: Type I and III collagen Elastin Proteoglycans Glycosaminoglycans (including hyaluronic acid) This mechanism helps restore structural integrity, improving firmness, elasticity, and volume over time

For tretinoin/niacinamide topical alone: Apply to dried skin at night, followed by moisturizer if needed

Higher concentrations have not demonstrated proportionally greater effects in available research

The peptide also shows potential DHT protection through copper ions inhibiting up to 90% of type 1 5-alpha reductase at specific concentrations, which targets the enzyme most involved in hair follicle miniaturization

Acromegaly, inflammation and cardiovascular disease: a review